References
The PhiTools software package is used in various scientific areas from experimental to pharmacological pre-clinical and clinical applications. An important list of peer-reviewed articles has already been published in international scientific journals, books or congress abstracts. Several additional works are in progress.
International journal articles
- Dauvilliers Y, Bisser S, Chapotot F, Vatunga G, Cespuglio R, Josenando T, Buguet A. Sleep 31(3):348-354 (2008).
Hypocretin and Human African Trypanosomiasis.
- Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Proc Natl Acad Sci U S A Jan 2 (2008).
Slow-wave sleep and the risk of type 2 diabetes in humans.
- Zoubek L, Charbonnier S, Lesecq S, Buguet A, Chapotot F. Biomed. Signal Process. Control 2:171-179 (2007).
Feature selection for sleep/wake stages classification using data driven methods.
- Quera Salva MA, Vanier B, Laredo J, Hartley S, Chapotot F, Moulin C, Lofaso F, Guilleminault C. Int J Neuropsychopharmacol. 10(5):691-6 (2007).
Major depressive disorder, sleep EEG and agomelatine: an open-label study.
- Latta F, Leproult R, Tasali E, Hofmann E, Van Cauter E. Sleep 28(12) 1525-34 (2005).
Sex differences in delta and alpha EEG activities in healthy older adults.
- Merica H, Fortune RD. Cereb. Cortex 15(7) 877-84 (2005).
Spectral power time-courses of human sleep EEG reveal a striking discontinuity at ~18Hz marking division between NREM-specific and wake/REM-specific fast frequency activity.
- Buguet A, Bisser S, Losenando T, Chapotot F, Cespuglio R. Acta Trop. 93(1) 107-17 (2005).
Sleep structure: a new diagnostic tool for stage determination in sleeping sickness.
- Darsaud A, Bourdon L, Mercier S, Chapotot F, Bouteille B, Cespuglio R, Buguet A. Sleep 27(1) 42-6 (2004).
Twenty-four hour disruption of the sleep-wake cycle and sleep-onset REM-like episodes in a rat model of African trypanosomiasis.
- Cervena K, Dauvilliers Y, Espa F, Touchon J, Matousek M, Billiard M, Besset A. J. Sleep Res. 13 385-93 (2004).
Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectrain psychophysiological insomnia.
- Merica H, Fortune RD. Sleep Med. Rev. 8(6) 473-85 (2004).
State transitions between wake and sleep, and within the ultradian cycle, with focus on the link to neuronal activity.
- Lavoie S, De Bilbao F, Haba-Rubio J, Ibanez V, Sforza E. Clin. Neurophysiol. 115(10) 2236-46 (2004).
Influence of sleep stage and wakefulness on spectral EEG activity and heart rate variations around periodic leg movements.
- Sforza E, Chapotot F, Lavoie S, Roche F, Pigeau R, Buguet A. Clin. Neurophysiol. 115(11) 2242-5 (2004).
Heart rate activation during spontaneaous arousals from sleep: effect of sleep deprivation.
- Sforza E, Chapotot F, Pigeau R, Naitoh P, Buguet A. Sleep 27(6) 1068-75 (2004).
Effects of sleep deprivation on spontaneaous arousals in humans.
- Roky R, Chapotot F, Taoudi-Benchekroun M, Hakkou F, Elkhalifi H, Benaji B, Buguet A. J. Sleep Res. 12(2) 95-101 (2003).
Daytime sleepiness during Ramadan intermittent fasting: polysomnographic and quantitative waking EEG study.
- Leproult R, Colecchia E, Berardi Am, Stickgold R, Kosslyn Sm, Van Cauter E. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284(2) R280-90 (2003).
Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated.
- Merica H, Fortune RD. Cereb. Cortex 13 1044_50 (2003).
A unique pattern of sleep structure is found to be identical at all cortical sites: a neurobiological interpretation.
- Chapotot F, Pigeau R, Canini F, Bourdon L, Buguet A. Psychopharmacology (Berl) 166(2) 127-138 (2003).
Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG.
- Sforza E, Grandin S, Jouny C, Rochat T, Ibanez V. Eur. Respir. J. 19 645-652 (2002).
Is waking electroencephalographic activity a predictor of daytime sleepiness in sleep-related Breathing disorders?
- Sforza E, Jouny C, Ibanez V. Clin. Neurophysiol. 113(6) 883-91 (2003).
Time-dependent variation in cerebral and autonomic activity during periodic leg movements in sleep: implications for arousal mechanisms.
- Roky R, Chapotot F, Hakkou F, Benchekroun M, Buguet A. J. Sleep Res. 10(4) 319-327 (2001).
Sleep during Ramadan intermittent fasting.
- Buguet A, Bourdon L, Bisser S, Chapotot F, Radomski Mw, Dumas M. Med. Trop. 61(4-5) 328-339 (2001).
La maladie du sommeil: trouble majeur des rythmes circadiens.
- Chapotot F, Buguet A, Gronfier C, Brandenberger G. Neuroendocrinology 73(5) 312-321 (2001).
HPA axis activity is related to the level of central arousal: effect of sleep deprivation on the association of high frequency waking EEG with cortisol release.
- Gaudreau H, Morettini J, Lavoie HB, Carrier J. Neurobiol. Aging 22(3) 461-8 (2001).
Effects of a 25-h sleep deprivation on daytime sleep in the middle-aged. - Chapotot F, Jouny C, Buguet A, Brandenberger G. Neuroreport 11(10) 2223-2227 (2000).
High frequency waking EEG: reflection of a slow ultradian rhythm in arousal.
- Sforza E,Jouny C, Ibanez I. Clin. Neurophysiol. 111 1611-1619 (2000).
Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response.
- Jouny C, Chapotot F, Merica H. Neuroreport 11(17) 3667-3671 (2000).
EEG spectral activity during paradoxical sleep: further evidence for cognitive processing. - Chapotot F, Gronfier C, Jouny C, Muzet A, Brandenberger G. J. Clin. Endocrinol. Metab. 83(12) 4263-4268 (1998).
Pharmacia & Upjohn Award.
Cortisol secretion is related to electro-encephalographic alertness in human subjects during daytime wakefulness.
Books, and Congress abstracts
- Buguet A, Chapotot F, Bisser S, Cespuglio R, Bouteille B. In: Sleep: a comprehensive handbook Lee-Chiong LT (Ed) Wiley, Hoboken 163-173 (2006).
Sleeping sickness: human African trypanosomiasis.
- Becq G, Charbonnier S, Chapotot F, Buguet A, Bourdon L, Baconnier P. In: Softcomputing in Knowledge Discovery - Methods and Applications Halgamuge S and Wang L (Eds) Springer Verlag. 8 113-127 (2005).
Comparison between five classifiers for automatic scoring of human sleep recordings.
- Buguet A, Bouteille B, Cespuglio R, Chapotot F. In: Les troubles du sommeil Billard M and Dauvilliers Y (Eds) Masson, Paris 309-323 (2005).
Maladies infectieuses et sommeil.
- Buguet A, Bisser S, Josenando T, Chapotot F, Cespuglio R, Dumas M. Rev. Neurol. 2S 151 (2005).
Polysomnographie: diagnostic non invasif du stade nerveux de la trypanosomose humaine africaine (THA).
- Cervena K, Dauvilliers Y, Espa F, Touchon J, Matousek M, Billiard M, Besset A. J. Sleep Res. 13(1) 129 (2004).
ESRS Sanofi-Aventis Awards.
Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectra in psychophysiological insomnia. - Leproult R, Tasali E, Saaresranta T, Pannain S, Miller J, Alverdy E, Van Cauter E. J. Sleep Res. 13(1) 444 (2004).
ESRS H Kristbjarnarson's Awards.
Morbidly obese women have less slow wave sleep than their age and gender matched controls. - Buguet A, Cespuglio R, Bisser S, Chapotot F, Josenando T, Dumas M. J. Sleep Res. 13(1) 109 (2004).
Polysomnography, a new means for human African trypanosomiasis stage diagnosis.
- Chevrier C, Chapotot F, Darsaud C, Cespuglio R, Buguet A, Bourdon L. J. Sleep Res. 13(1) 135 (2004).
Chronobiological alterations in sleep-wake stages and core temperature in experimental african trypanosomiasis.
- Quera-Salva M, Laredo J, Chapotot F, Vannier B, Bohic M, Moulin C, Morlat D, Bodinat C, Lofaso F, Guilleminault C. J. Sleep Res. 13(1) 593 (2004).
Sleep EEG during a major depression episode in patients consulting for a sleep/wake complaint.
- Chapotot F, Becq G, Sforza E, Buguet A. J. Sleep Res. 13(1) 132(2004).
Automatic sleep-wake stage scoring using artificial neural networks: optimisation and evaluation.
- Chapotot F, Bisser S, Panzo A, Josenando T, Buguet A. J. Sleep Res. 13(1):13 (2004).
EEG slow-wave activity: a potential marker of the nervous phase of human African trypanosomiasis.
- Becq G, Charbonnier S, Chapotot F, Buguet A, Bourdon L, Baconnier P. In: Proceedings of the 1st international conference on fuzzy systems and knowledge discovery: Computational intelligence for the E-age Wang L, Halgamuge S, Yao X (Eds) Orchid Country Club (1) pp166 (2002).
Comparison between five classifiers for automatic scoring of human sleep recordings.
- Chapotot F, Pigeau R, Naitoh P, Buguet A. Methods and Findings in Experimental and Clinical Pharmacology 24D 154 (2002).
IPEG-PAREXEL Young Scientist Awards
Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian regulation of the human waking EEG. - Chapotot F, Buguet A, Brandenberger G. Stress 5 84 (2002).
Alteration of the ultradian coupling between waking EEG arousal and HPA axis activity during sleep deprivation.
- Sforza E, Jouny C, Ibanez V. J. Sleep Res. 11(1) 416 (2002).
Temporal evolution of arousal response during periodic leg movements: Evidence for circadian influence. - Buguet A, Tapie P, Chapotot F, Banzet S, Bogui P, Cespuglio R. J. Sleep Res. 11(1) 30 (2002).
Sleep in tropical Africa: At the laboratory in villages without electrical power. - Buguet A, Tapie P, Bisser S, Chapotot F, Doua F, Cespuglio R. J. Sleep Res. 11(1) 29 (2002).
Sleep in sleeping sickness patients under ambulatory monitoring. - Chapotot F, Buguet A, Brandenberger G. J. Sleep Res. 11(1) 36 (2002).
Sleep deprivation alters the ultradian coupling between waking EEG arousal and HPA axis activity. - Chapotot F, Pigeau R, Buguet A. Actas di Fisilogia 7 254 (2001).
Distinctive effects of Modafinil and d-amphetamine on the human EEG power spectrum during 60 uninterrupted waking hours. - Darsaud A, Mercier S, Chapotot F, Bouteille B, Chevrier C, Canini F, Bourdon L, Cespuglio R, Dumas M, Buguet A. Med. Trop. 61(3) 280 (2001).
Rythmes circadiens de la vigilance dans la trypanosomose africaine: étude numérique chez le rat.
- Jouny C, Chapotot F, Merica H. Sleep Res. Online 2(1) 47 (1999).
REM-related EEG spectral changes during paradoxical sleep in humans. - Chapotot F, Jouny C, Buguet A, Brandenberger G. Sleep Res. Online 2(1) 252 (1999).
Temporal relationships between EEG frequency bands in awake man. - Chapotot F, Jouny C, Buguet A, Brandenberger G. Sleep Res. Online 2(1) 176 (1999).
Increased HPA activity during sleep deprivation in man. - Chapotot F, Gronfier C, Jouny C, Muzet A, Brandenberger G. J. Sleep Res. 7(2) 44 (1998).
Cortisol secretion is temporally related to EEG beta activity during wakefulness in man.
Multimedia
- Chapotot F. Journees dediees aux applications pharmaceutiques et medicales avec l'environnement MATLAB. Sevres (2005).
PRANA : Une boite à outils MATLAB pour l'analyse des enregistrements polygraphiques.
- Tung J, Oxenford R. MATLAB News and Notes Spring (2001).
Analyzing data for sleep research.
PhiTools provides advanced software solutions and services for biosignal processing, sleep analysis, psychophysiological research and clinical trials. PhiTools, software tools and services for psychophysiology, polysmonography and chronobiology.

